Eosinophil Infiltration in Airways of Mice Exposed to Toluene Diisocyanate

Eosinophil infiltration in airways of mice exposed to toluene diisocyanate.

Toluene diisocyanate (TDI) is a chemically reactive low-molecular-weight compound widely used in industries as a polymerizing agent in the production of polyurethanes. TDI has been reported as one of the most important causes of occupational asthma. Clinical investigations have shown that asthma is an inflammatory disorder of the airways and is referred to as chronic eosiniopilic bronchitis . E...

Antibodies to toluene diisocyanate in an environmentally exposed population.

Residents living near a polyurethane foam manufacturing facility expressed concern to health officials over chemical emissions from the plant. Environmental monitoring of ambient air near the plant indicated the presence of toluene diisocyanate (TDI), which was used in foam production. Health officials collected blood samples from 113 residents and analyzed the blood sera for antibodies to TDI ...

IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to Toluene Diisocyanate Vapor

OBJECTIVES We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. METHODS Wistar rats were exposed to two different concentrati...

Inhalation of toluene diisocyanate vapor induces allergic rhinitis in mice.

Diisocyanates are the leading cause of occupational asthma, and epidemiological evidence suggests that occupational rhinitis is a comorbid and preceding condition in patients who develop asthma. The goal of the present studies was to develop and characterize a murine model of toluene diisocyanate (TDI)-induced rhinitis. Female C57BL/6 mice were exposed to workplace-relevant concentrations of TD...

Induces Allergic Rhinitis in Mice Inhalation of Toluene Diisocyanate Vapor